While playing host to the Fantastic Four at Avengers Mansion, the Avengers find themselves under attack by Doctor Doom's forces.
Seeking revenge against Tony Stark, the leader of AIM seizes control of Stark Enterprises' corporate tower.
The Enchantress is on a vindictive hunt for Baron von Zemo and he appeals to the Avengers for help against her.
Ronan the Accuser of the Kree Empire arrives at Earth with Captain Mar-Vel in tow to pass judgment on whether the planet should be annexed or destroyed.
When Henry Pym discovers that his Ant-Man equipment has been stolen and being used by a criminal, he hires Heroes for Hire to recover it.
The Avengers receive a man who appears to have been experimented on by aliens, and now hunted by another extraterrestrial group.
Iron Man learns from Nick Fury that the Avengers has been infiltrated by a Skrull impostor and the team turns against each other.