The missing tennis player character is named Deanna Sirtis, an obvious play on Marina Sirtis, who played Deanna Troi In Star Trek: The Next Generation (1987).
When Shawn visits the retreat with Gus, he introduces himself as Jerry Hathaway, the name of William Atherton's character in Real Genius.
When Shawn is pretending to imitate the Tommy Lee Jones speech from "The Fugitive," the last House he mentions is "House of the Long Shadows." This is actually a real film, starring four of the greats of the horror/suspense genre - Vincent Price, Christopher Lee, John Carradine, and Peter Cushing.
Shawn claims to have worked on the "mono-theo-huxtable drug." This refers to an ongoing joke about Gus looking like the guy on "The Cosby Show."

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